Patients: Parkinson's, tremor, dystonia, chorea, myoclonus, dyskinesia, SCA, rare diseases, dementia, spastic paraplegia. Includes gene testing subjects & Parkinson's association members.
Led by Prof. Ching-Sung Lu, the Neuroscience Center at Linkou Chang Gung Memorial Hospital establishes the service "Innovation and Integration of Movement Disorders." It boasts the most comprehensive movement disorder team in Taiwan and Asia, with 11 defect specialists and 26 members—surpassing NTU (5/18), Beijing Tiantan (3), Kyoto U (3), Stanford (7/15), UPenn (10/19), UBC (15/19), and UCL (8). Three Major Features: (1) Specialized Clinical Care (expanding patient associations and cross-team care networks); (2) Comprehensive Gene Exploration (testing 11 Parkinson's genes like SNCA/PRKN/LRRK2, 10 dystonia genes like TOR1A/GCH1, and SCA, dementia, HSP, Huntington's, supporting hospitals nationwide); (3) Translational Research (e.g., Sialidosis study in 2013 J Clin Neurosci with Prof. C.H. Tsai at CMU). Three Innovations: (1) First to identify LRRK2 G2385R mutation as the key Parkinson's risk factor for Taiwanese/Asians (absent in Caucasians), tracing to a common ancestor 4,800 years ago; (2) Invented Theta Burst Stimulation (TBS) by Dr. Y.R. Huang in 2005 (Neuron, IF 15.982, 822 citations), globally used for depression/dystonia, and complied with the 2008 Siena safety consensus; (3) Developed 99mTc-TRODAT-1 imaging (the 1st TFDA-approved, NHI-fully-covered NT$10,000 radiopharmaceutical for PD; world's largest database of 7,000+ cases; 700+ cases annually) and 18F-DTBZ PET imaging for differential diagnosis.
Most complete movement disorders team in Taiwan & Asia
11 movement disorders attendings (exceeds intl benchmarks)
World-first LRRK2 G2385R discovery (Han Chinese unique)
World-first Theta-burst TMS (TBS)
99mTc-TRODAT-1 Taiwan-first Parkinson imaging
18F-DTBZ PET VMAT2 differential diagnosis
11 movement disorders attendings
26 total center staff
7,000+ 99mTc-TRODAT visits
700+ Parkinson patients/year benefiting
Covers 11 Parkinson-related gene tests
10 dystonia-related gene tests
World's largest 99mTc-TRODAT database (7,000+)
Neuron IF 15.982 TBS paper cited 822 times
Full NHI coverage NT$10,000 DAT exam
LRRK2 G2385R Parkinson risk: world-first publication
Sialidosis clinical translation in J Clin Neurosci 2013
TBS applied in 4 areas (depression, dystonia, etc.)
MOHW-approved 99mTc-TRODAT-1
Complete animal & human trial process
Complies with 2008 Siena international safety/ethics consensus
TBS international application safety guidelines
Cross-specialty team integration
Standardized molecular diagnosis
Continuously expanding Parkinson patient association
Adequate accurate medical information
Appropriate drug treatment
Safe exercise modalities
Complete psychological education
Adequate social support
Neuron IF 15.982 cited 822 times
Brain 2014 & Curr Opin Psychiatry 2012 citations
Invited to author chapters in 4 international books
Benchmarked vs Stanford, UBC, UCL London, U Penn
Benchmarked vs Kyoto U, Beijing Tiantan
Self-developed 99mTc-TRODAT applied worldwide
Leads movement disorders medicine in Taiwan and Asia
Trains national movement disorders subspecialists
Supports domestic hospital gene testing
99mTc-TRODAT provides world-class research recognition
TBS as international research guidelines
Parkinson gene-based drug development
