葡萄王猴頭菇菌絲體原料特色在於獨特的菌絲體活性物質Erinacine，能促進神經生長因子(NGF)分泌，對神經健康和抗衰老有顯著效果；在生產技術上，葡萄王生技透過特有菌株選育和液態發酵技術，開發出全球唯一的40噸級發酵槽技術，專門生產高濃度猴頭素A(>5 mg/g)的菌絲體，同時含有猴頭素C及S等活性成分。 在研究發表方面，葡萄王過去十年發表38篇SCI論文，安全性研究完整，包括各項毒性測試。此外，已完成3項人體臨床研究，另有2項進行中，並已取得16件專利，展現了葡萄王在猴頭菇研發領域的領導地位。

美國New Dietary Ingredient (NDI) Notification 清真認證 其他

猴頭菇菌絲體粉

猴頭素Ａ 5 mg/g(w/w)以上

製造廠名稱: 葡萄王生技股份有限公司 製造廠登記: H-111880517-00003-9, 製造廠品管: FSSC22000 GMP HACCP ISO22000

原料貯存條件(溫度、溼度)每日監控 菌種液態氮(L-N2)保存，每年測試存活率及生長速度。 2. 三角瓶種菌於無菌操作台接種入百升級發酵槽，每三個月測定落菌試驗。 3. 以API ZYM管制種菌槽品質後，再接種入噸級發酵槽。 4. 發酵品管紀錄表(顏色氣味、鏡檢、pH 值、殘餘葡萄糖、汙染菌生菌數培養) 5. 發酵參數每日監控 6. 凍乾及分裝製程採無塵室標準100,000等級以上 採用薄膜離心減壓濃縮設備於55度下，於一秒鐘中內濃縮10倍，降低熱破壞。

出廠檢驗報告(COA)含Erinacine A功效成分。 2.全球獨創發酵生產菌種鑑定報告(ITS1相似度≧99.5%)。 3.全球獨創以API ZYM快速管制雜菌汙染。 4. 全球獨創每批發酵粉末皆進行委外急毒性試驗(in vivo)，並列為入庫驗收依據

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Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation. Front Pharmacol. 15;10:1174 2019 20. Thirteen-Week Oral Toxicity Evaluation of Erinacine A-Enriched Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Sprague-Dawley Rats. Int J Med Mushrooms 21:401-404 2019 21. Effects of Hericium erinaceus Mycelium Extracts on the Functional Activity of Purinoceptors and Neuropathic Pain in Mice with L5 Spinal Nerve Ligation. Evid Based Complement Alternat Med. 2020: 2890194，2020 22. Hericium erinaceus enhances neurotrophic factors and prevents cochlear cell apoptosis in senescence accelerated mice. J. Funct. Food 66:103832 2020. 23. Post‐Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson’s Disease. Antioxidants 9, 137 2020 24. 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