Arteriovenous malformation patients
Cerebral cavernous malformation patients
Sigmoid/cavernous sinus dural AV fistula patients
Large/giant AVM patients
High-risk vascular lesions
Gamma Knife trainees
Taipei VGH Gamma Knife Radiosurgery Team, led by Drs. Wan-Yuo Guo and Cheng-Chia Lee, integrates Functional Neurosurgery, Neuroradiology, and Radiation Oncology as Taiwan's only team performing both pre- and post-op outcome evaluation. Past 10 years: 1,602 AVM cases treated, gamma knife accounting for 72.5% (1,162). Eight world-first innovations: (1) treatment of giant AVMs; (2) volume-staged technique for brain AVMs; (3) dosimetry boosting large AVM cure rate while reducing risk; (4) MRI perfusion to validate gamma knife efficacy (AJNR Cover Story); (5) application of quantitative DSA (QDSA); (6) MRI-based follow-up replacing DSA; (7) AI-based outcome prediction model; (8) world-exclusive patent for AI auto-segmentation of brain AVM tissue (sensitivity 89.86%, specificity 92.36%; ROC Taiwan I637187 & US 10,346,719 B2 patents). AVM cure rate 60-90% with rebleeding <2%; DAVF cure rate >75% with case volume comprising half of global cases; CCM rebleeding reduced from 23.6-31.3% to 1.74-3.2%. Published 110 academic papers in JNS/NSGY/AJNR/Red Journal.
Multidisciplinary team (Neurosurg/Neuroradiol/Rad Onc)
World-first giant AVM treatment
World-first volume-staged technique
World-first MRI follow-up replacing DSA
World-exclusive AI AVM segmentation patent
Taiwan-only pre/post-op evaluation team
32 Years of Gamma Knife Treatment for AVMs:1315 Cases
DAVF cases comprise half of global total
Largest CCM case series worldwide
110 cerebral vascular malformation papers
Established multiple domestic/intl gamma knife centers
AVM cure rate 60-90%, rebleeding <2%
DAVF cure rate >75%
CCM rebleeding 23.6-31.3% → 1.74-3.2%
AVM/CCM post-op seizure control: TPE VGH highest
AI auto-segmentation sensitivity 89.86%, specificity 92.36%
Best large-AVM treatment outcomes globally
Multi-modal stereotactic image-guided QA
MRI + X-ray angiography integration since 1993
Open-craniotomy-free, no post-op ICU
Significantly reduced large AVM treatment risk
Small 12Gy field outside lesion, high coverage
Aligned with IRRF, Asian Gamma Knife Academy education
Patients praise open-craniotomy-free option
Significantly improves post-op health & quality of life
Intl patients seek treatment abroad
Media coverage and public acclaim
Dr. Hideyuki Kano (UPMC) endorses TPE VGH approach
Patient family appreciation
110 cerebral vascular malformation papers
Published in JNS/NSGY/AJNR/Red Journal
AJNR Cover Story feature
World-exclusive AI patents (ROC/USA)
Faculty for IRRF and Asian Gamma Knife Academy
Comparative data from 32 countries; intl talks
Established Gamma Knife centers at Shuang Ho, CSMU, Chiayi VGH, KSVGH
Trained physicians from Shanghai, Singapore, India, Sweden
AI smart medical device development with NYCU
Led Taiwan Smart Healthcare Alliance (TSHA)
TPE VGH DAVF treatment = global standard
Domestic/intl gamma knife demonstration center
