Protygold® is a small molecular peptide derived from walnut protein through a patented, eco-friendly processing technology. It undergoes solvent-free cold-pressing for defatting, followed by enzymatic hydrolysis and purification, resulting in a powder with over 75% peptide content and a low molecular weight (200-500 Da) for enhanced absorption. This walnut oligopeptide offers significant brain health benefits. It provides neuroprotection by reducing oxidative stress and inhibiting amyloid-beta aggregation, thereby slowing neuronal damage. Furthermore, it enhances cognitive functions by upregulating Brain-Derived Neurotrophic Factor (BDNF), which supports neural growth, strengthens synaptic connections, and improves learning and memory. Additionally, Protygold® improves sleep quality by increasing the expression of GABA receptors, promoting a calming effect alongside GABA. In summary, Protygold® is an emerging, science-supported ingredient that offers a novel option for cognitive and sleep support in the market.
In quality management, Sinphar’s strength lies in seamless alignment with international standards and dynamic process control. With over 20 years of experience in developing natural plant ingredients, the company has a deep grasp of the technical nuances across various product categories and proactively monitors regulatory changes in different global markets. Sinphar holds multiple international certifications, including GMP, ISO 22000, HACCP, ISO 14001:2015, Halal, and Kosher. It regularly reviews and updates internal quality standards to keep its management system fully synchronized with global benchmarks. This ensures that the company’s products and services consistently meet—and often exceed—the increasingly stringent demands of international customers, providing solid yet flexible compliance support for their smooth entry into global markets.
Walnut oligopeptide
Protein, peptide content, Protein hydrolysate（Relative molecular weight should less than 2000）
Sinphar Tian-Li Pharmaceutical Co., Ltd. (Hangzhou)
Daily monitoring of raw material storage conditions (temperature, humidity)
Production process monitoring and recording
Daily monitoring of finished product storage conditions (temperature, humidity)
Routine quality control measures from raw materials to finished products
Stability test
Heavy metals — Arsenic, Lead, Cadmium, Mercury
Microorganisms — Total plate count, Coliforms, Mold, Salmonella, Staphylococcus aureus
Aflatoxin
Pesticide residues — 422 items test
Plasticizers — 9 items test
Walnut raw material quality standards and test reports
Walnut residue raw material quality standards and test reports
Test reports for auxiliary materials and packaging materials used during production
Full-panel test report conducted by a third party once per year
Stability reports: product and raw material reports
Product traceability system
Reduce oxidative stress, thereby exerting a neuroprotective effect.
Demonstrate memory-improving efficacy using an animal model of memory impairment.
Human clinical trials confirm its benefits in enhancing memory and cognitive function, as well as improving sleep quality. Meanwhile, zebrafish model studies reveal that these effects are mediated by increasing GABA and melatonin receptors.
(2016). A simple and convenient method for the preparation of antioxidant peptides from walnut (Juglans regia L.) protein hydrolysates. Chemistry Central Journal 10:39
(2019). Neuroprotective and memory-enhancing effects of antioxidant peptide from walnut (Juglans regia L.) protein hydrolysates.Natural Product Communications.
(2019)Walnut protein isolates attenuate particulate matter-induced lung and cardiac injury in mice and zebra fish. RSC Advances 40736
(2022)Walnut (Juglans regia L.) Oligopeptide Effects on Enhancing Memory, Cognition and Improving Sleep Quality in Teenagers and Elderly People in a Randomized Double-Blind Controlled Trial. Natural Product Communications Volume 17(3): 1–8
China (CN 105567774 B): Walnut oligopeptide powder, preparation method and use thereof
China (CN 105936927 B): Walnut oligopeptide, preparation process and use thereof
China (CN 107446975 B): High-purity walnut oligopeptide and industrial preparation method thereof
Taiwan (TWI782283 B): Use of walnut oligopeptide powder
China (CN 107440114 B): Composition having efficacy against PM2.5 particulate matter
China (CN 107439787 B): Walnut oligopeptide having efficacy against PM2.5 particulate matter
China (CN 109589400 B): Composition having neuroprotective efficacy
WALNUT OLIGOPEPTIDE POWDER, PREPARATION METHOD AND APPLICATION THERE OF: Japan (JP6828054B2) ,Australia (AU2017209066B2), EU(EP3406625B1) , Indonesia (IDP000069231), Korean (KR102320465B1) , US (US11072637B2), Malaysia (MY193780)
